22 down: Worker with practically nothing? That smells! (6)
I was pretty sure this was making reference to a nose, but I had no idea that a slang term for nose is beezer, so that worker = bee and practically nothing = zer, giving worker with practically nothing? = beezer = that smells!.
25 across: Brief spy issue (6)
I had never heard of Molson as a beer, and here we have spy = mole, brief spy = mol and issue = son (which I’m not completely sure about), giving brief spy issue = Molson = beer (the crossword’s theme).